2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
  4. Na+/K+ ATPase

Na+/K+ ATPase

Sodium potassium pump

Na+/K+ ATPase

Related Products

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Na+/K+ ATPase (Sodium potassium pump) is a transmembrane protein complex found in all higher eukaryotes acting as a key energy-consuming pump maintaining ionic and osmotic balance in cells. Na+/K+ ATPase is an emerging cancer target that merits further investigation.

The constant activity of the Na+/K+-ATPase (NKA, or Na+ pump) is essential for re-establishing and maintaining this gradient. In cardiac and vascular smooth muscle the principal isoforms of the NKA are α1 and α2 and their physiological role is controlled both by their unique and independent signalling pathways, and their discrete subcellular distribution.

Na+/K+ ATPase Related Products (48):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-158292
    Digoxin-OVA
    		Inhibitor
    Digoxin-OVA is one of protein/peptide and small molecule drug conjugates (PDCs), consisting of Digoxin (HY-B1049) and OVA. PCDs are promising targeted therapeutics with better cell permeability and drug selectivity than antibody-drug conjugates (ADCs). PDCs have been widely used in research on cancer, COVID-19, and metabolic diseases.
    Digoxin-OVA
  • HY-N11690
    Oleandrigenin
    		Inhibitor
    Oleandrigenin is a potent cardiotonic steroid. Oleandrigenin shows Na+/K+-ATP-ase inhibiting and cytotoxic activities.
    Oleandrigenin
  • HY-N1446S4
    Oleic acid-13C-1
    		Activator
    Oleic acid-13C-1 is the 13C labeled Oleic acid. Oleic acid (9-cis-Octadecenoic acid) is an abundant monounsaturated fatty acid[1]. Oleic acid is a Na+/K+ ATPase activator[2].
    Oleic acid-<sup>13</sup>C-1
  • HY-P3711
    SPAI-1
    		Inhibitor
    SPAI-1 is a specific inhibitor for monovalent cation transporting ATPases. SPAI-1 is a peptide isolated from porcine duodenum, inhibits Na+, K+-ATPase and H+, K+-ATPase in vitro, stimulates Mg2+-ATPase.
    SPAI-1
  • HY-116050
    17(S)-HETE
    		Inhibitor
    17S-HETE is arachidonic acid metabolite through cytochrome P-450 pathways. 17S-HETE serves as allosteric activator of the cytochrome P450 1B1 and inhibitor of ATPase, induces cardic hypertrophy.
    17(S)-HETE
  • HY-B0137B
    Prilocaine acetate
    		Inhibitor
    Prilocaine acetate, an amino amide, is a Na/K-ATPase inhibitor. Prilocaine acetate has neurotoxic effects.
    Prilocaine acetate
  • HY-B0137A
    Prilocaine hydrochloride
    		Inhibitor
    Prilocaine hydrochloride, an amino amide, is a Na, K-ATPase inhibitor. Prilocaine has neurotoxic effects.
    Prilocaine hydrochloride
  • HY-N6745S
    Citreoviridin-13C23
    		Modulator
    Citreoviridin-13C23 is 13C labeled 2,3-Pentanedione (HY-W012998). 2,3-Pentanedione is a common constituent of synthetic flavorings and is used to impart a butter, strawberry, caramel, fruit, rum, or cheese flavor in beverages, ice cream, candy, baked goods, gelatins, and puddings. 2,3-Pentanedione also occurs naturally as a fermentation product in beer, wine, and yogurt and is releasedduring roasting of coffee beans.
    Citreoviridin-<sup>13</sup>C<sub>23</sub>